There is no definitive answer to this question since it can vary depending on the specific firearm and muzzle brake combination. In general, however, muzzle brakes can affect accuracy by slightly changing the harmonics of the barrel, which can impact bullet trajectory. Additionally, muzzle brakes can create more muzzle flashes, which can make it more difficult to control the weapon.
Some shooters are able to compensate for these effects and still maintain good accuracy, while others may find that their overall performance suffers.
Experimenting with different setups to see what works best for you and your rifle is important.
Martin Mapa Edited answer September 18, 2022